Application of real options analysis for pharmaceutical R&D project valuation—Empirical results from a survey     

Marcus Hartmann  Ali Hassan 《Research Policy》2006,35(3):343-354

Real options analysis was often recommended as an emerging valuation technique for high-risk investment projects. Former inter-sectoral surveys have drawn an ambivalent picture of real options usage in general. In addition, there is a lack of sector-specific investigations. In the following article the results of an in-depth analysis of collected empirical data regarding the application of this new tool in the pharmaceutical sector is presented by capturing the internal view from the pharmaceutical companies themselves and the external view from the health care departments of financial service firms. R&D stage specific modi of application, reasons for reluctance in the employment of real options and their assumed future prospects are elucidated.  相似文献   

Reliability and Validity of Real-Time Response Measurement: a Comparison of Two Studies of a Televised Debate in Germany   总被引：1，自引：0，他引：1  

Maier  Jurgen; Maurer  Marcus; Reinemann  Carsten; Faas  Thorsten 《Int. Journal of Public Opinion Research》2007,19(1):53-73

This paper investigates the reliability and validity of real-timeresponse measurements (RTR). It is based on a comparison oftwo quasi-experimental studies independently conducted on thesecond televised debate of the two major candidates for chancellorin the 2002 German federal election campaign. Participants inBamberg and Mainz—two mid-sized German cities—followedthe debate on a large-scale screen. The viewers’ immediatereactions to the candidates were measured in real-time. In termsof technicalities and substance, both quasi-experiments differedin several important respects. For example, the system usedin Mainz was based on a control unit with a 7-point scale andyielded one merged metric dimension for both candidates. TheBamberg system measured positive and negative impressions ofthe candidates independently, yielding categorical data. Despitethese operational differences, the results show that both methodsrender reliable results that also meet the criteria of face,construct, and criterion validity. Hence, RTR measurements providevaluable, unique insights into subjective immediate reactionsto candidates in televised debates and help to explain post-debateperceptions and attitudes. Received for publication March 23, 2005. Revision received December 14, 2005.  相似文献   

Using Art Media During Prewriting: Helping Students with Dysgraphia Manage Idea Generation Before Encoding Text     

Michael Dunn 《Exceptionality》2013,21(4):224-237

Many students struggle with writing skills. This study focuses on three students (second and fourth grades) who were classified with a learning disability by their school. These children had writing goals and objectives (i.e., characteristics of having dysgraphia) included in their Individual Education Plan. In a single case design format, each student was taught the Ask, Reflect, Text (ART) mnemonic strategy to help improve story content and quality. The components of ART include students Ask themselves a series of seven questions; the students then Reflect on their answers and illustrate their story-content responses with art media (e.g., paints, colored markers, play dough); and from this prewrite illustration, students generate their Text. All participants improved greatly in story content. They also improved in story quality but to a lesser extent.  相似文献   

And Never the Twain Shall Meet: One Student's Practical Theory Encounters Constructivist Teacher Ed Practices     

Deborah Burk Rodgers  Maylan Dunn 《Journal of Early Childhood Teacher Education》2013,34(3):10-25

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The world of work     

Sonja Dunn 《Early Childhood Education Journal》1988,16(1):34-35

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The Role of Research in Teacher Education     

S. S. Dunn 《Asia-Pacific Journal of Teacher Education》1977,5(3):172-175

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Effect of exertional trend during cycle ergometry on postexercise affect     

Kilpatrick M  Hebert E  Bartholomew J  Hollander D  Stromberg D 《Research quarterly for exercise and sport》2003,74(3):353-359

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Techniques used in high-scoring and low-scoring 'Roche' vaults performed by elite male gymnasts     

Takei Y  Dunn JH  Blucker E 《Sports biomechanics / International Society of Biomechanics in Sports》2003,2(2):141-162

The 16 highest-scored Roche vaults (G1) performed during the 2000 Olympic Games were compared with those receiving the 16 lowest-scores (G2). A 16-mm motion picture camera operating at 100 Hz recorded the vaults during the competition. The results of t tests (p < .05) indicated G1, compared to G2, had (a) shorter time of board support, greater normalised average upward vertical force and backward horizontal force exerted by the board, greater change in the vertical velocity while on the board, and greater vertical velocity at board take-off, (b) comparable linear and angular motions in pre-flight, (c) smaller backward horizontal impulse exerted by the horse, smaller loss of the horizontal velocity while on the horse, and greater horizontal and vertical velocities at horse take-off, (d) greater height and larger horizontal distance of post-flight, (e) higher body mass centre at knee release, and (f) higher mass centre, greater normalised moment of inertia, and smaller vertical velocity at mat touchdown. Therefore, gymnasts and coaches should focus on sprinting the approach; blocking and pushing-off the take-off board rapidly and vigorously; departing the board with a large vertical velocity; exerting large downward vertical force and small forward horizontal force from the hand-stand position while on the horse; departing the horse with large horizontal and vertical velocities; and completing the majority of the double salto forward near the peak of trajectory and releasing the knees above the top of the horse to prepare for a controlled landing.  相似文献   

Somersaulting techniques used in high-scoring and low-scoring Roche vaults performed by male Olympic gymnasts     

Takei Y  Dunn JH  Blucker EP 《Journal of sports sciences》2007,25(6):673-685

The aim of this study was to compare the somersaulting techniques used in the 16 highest-scoring and 16 lowest-scoring Roche vaults. Our hypothesis was that the gymnasts performing the highest-scoring Roche vaults would demonstrate a better technique than those performing the lowest-scoring Roche vaults while on the horse (pushing off the horse more effectively), somersaulting (executing most of the required somersaults higher in flight), and landing (showing a greater control). A 16-mm motion picture camera, operating at 100 Hz, recorded the vaults during the official competition. The two-dimensional direct linear transformation was used for spatial reconstruction. The results of t-tests (P < 0.05) indicated that, compared with the low-scoring gymnasts, the high-scoring gymnasts had: (1) greater height of body centre of mass and a more fully extended body position at the horse take-off; (2) greater height of body centre of mass at the peak of post-flight, knee release, and touchdown on the mat; (3) greater horizontal and vertical displacements of body centre of mass, greater somersaulting rotation, and longer time from the knee release to mat touchdown; and (d) markedly smaller landing point deductions. In conclusion, a successful Roche vault is likely when the focus is on: (a) leaving the horse with a large vertical velocity in an extended body position to achieve a high trajectory of centre of mass by first extending the legs, then immediately pushing off the horse vigorously, using the muscles of the upper extremity; (b) grasping the knees immediately after the take-off from the horse, achieving the tightly tucked body position early during the ascent to the peak, and completing two-thirds of the required somersaults at a great height; (c) releasing the knees and extending the body above the top level of the horse; and (d) contacting the mat with a high body centre of mass position.  相似文献   

Medical student, resident, and faculty use of a computerized literature searching system     

R J Markert  A J Parisi  H V Barnes  S Cohen  K Goldenberg  L E Mieczkowski  M Dunn  R M Siervogel 《Bulletin of the Medical Library Association》1989,77(2):133-138

The experiences of medical students, residents, and faculty with a computerized literature searching system were evaluated. Third-year medical students, internal medicine and family practice residents, and full-time and voluntary faculty at one medical school had the opportunity to use a full-text and bibliographic medical literature retrieval system free of charge for an eleven-month period. Subjects conducted nearly nine thousand literature searches over a period of 942 system hours. Questionnaire data showed that participants could learn to use and would use an electronic information system, felt capable of using the system, utilized the system for a variety of purposes and in a number of different ways, and viewed the system as a valuable tool in searching the medical literature. The results are discussed in the context of the educational needs of the four user-groups and medical education planning by institutions.  相似文献